Publications

Latest publication 09/10/2018

Cysteamine Potentiates the Anti-Depressive Effects of Venlafaxine in Corticoster

The hypothalamic-pituitary-adrenal (HPA) axis abnormalities have been linked to the occurrence of severe depressive and anxiety states....

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    [title] => Cysteamine Potentiates the Anti-Depressive Effects of Venlafaxine in Corticoster
    [paragraph] => Cysteamine Potentiates the Anti-Depressive Effects of Venlafaxine in Corticosterone-Induced Anxiety/Depression Mouse Model: Effect on Brain-Derived Neurotrophic
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Authors
E Ahmed, MK Tawfik, SS Essawy, AS Ahmed et al

 Lab
Neuropharmacology Group, Institute of Neuroscience, Université Catholique de Louvain, Brussels, Belgium
Journal
Egyptian Journal of Basic and Clinical Pharmacology
Abstract
The hypothalamic-pituitary-adrenal (HPA) axis abnormalities have been linked to the occurrence of severe depressive and anxiety states. Venlafaxine, a serotonin and a noradrenaline reuptake inhibitor (SNRI), is an approved antidepressant agent with evidence of non-response to treatment in a subset of patients. In this study, 48 male mice (30-38 g) were used to evaluate the possible anxiolytic and antidepressant in_uence of intraperitoneal (i.p.) cysteamine (150 mg/kg/day) on i.p. venlafaxine (10mg/Kg and 20mg/Kg), as well as e_ects on brain-derived neurotrophic factor (BDNF) level and tropomyosin-related kinase B (TrkB) gene expression in prefrontal cortex (PFC) in corticosterone-induced anxiety/depression mouse model. The present results provided evidence on insu_cient venlafaxine anxiolytic and antidepressant e_ects in this model. However, cysteamine combined with venlafaxine caused signi_cant antidepressant behavioral e_ects together with a signi_cant increase in BDNF levels followed by TrkB receptor downregulation in mice PFC. In conclusion, we highlight the potential use of a combination therapy of venlafaxine and cysteamine as a therapeutic strategy for glucocorticoid-related symptoms of depression
BIOSEB Instruments Used
Forced Swimming Test: New FST DUAL SENSOR (BIO-FST-DSM)
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Combining a double input from vibrations and video,
 the TYC (Train-Your-Computer) algorithm compares both inputs to determine the animal's behavior in real time, making results completely operator-independent.

Experiment manager, analysis module, replay possibilities and the TYC algorithm are some of the features that make FST DUAL SENSOR a very innovative and easy to use instrument for both mice or rats studies (up to 4 animals can be tested at a time), based on the famous Porsolt Test, or "behavioral despair" test

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