Publications

Latest publication 04/01/2025

Niclosamide extends health span and reduces frailty by ameliorating mTORC1 hyper

Frailty is characterized by an increased vulnerability to disease and physical debilitation due to a decline in the body’s capacity to...

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    [title] => Niclosamide extends health span and reduces frailty by ameliorating mTORC1 hyper
    [paragraph] => Niclosamide extends health span and reduces frailty by ameliorating mTORC1 hyperactivation in aging models
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Authors
Pyeong Geun Choi, Hee Soo Kim, So-Hyun Park, Hyo-Deok Seo, Jeong-Hoon Hahm, Yang Hoon Huh, Tae-Il Jeon, Jiyun Ahn, Chang Hwa Jung



 Lab


Journal
Journal of Advanced Research


Abstract
Frailty is characterized by an increased vulnerability to disease and physical debilitation due to a decline in the body’s capacity to maintain homeos…


Keywords/Topics
Aging;Caenorhabditis elegans;Health span;Longevity;Sarcopenia;Skeletal muscle
BIOSEB Instruments Used:
Grip strength test (BIO-GS4)

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An easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins, muscular (i.e. myopathy) and neurodegenerative diseases on muscular degeneration. It is widely used in conjunction with the ROTAROD motor coordination test: a normally coordinated rodent will show a decreased latency to fall off the rotating rod if its muscular strength is low. The Grip Strength Test is a must for your research on activity, motor control & coordination, and is particularly well suited for studies on Parkinson's & Huntington's disease.


New features GS4 - 2023: Color display with permanent backlight screen for easier reading, reset by footswitch, Improved battery time, Larger data memory of 500 values, Animal counter, USB port (charging/data transfer)


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