Publications

Latest publication 06/22/2026

Bottlebrush polymer conjugates for enhanced antisense oligonucleotide therapy in

. Oligonucleotides are a promising class of genetic medicine for myotonic dystrophy type 1 (DM1), the most common adult-onset muscular dystrophy. H

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    [title] => Bottlebrush polymer conjugates for enhanced antisense oligonucleotide therapy in
    [paragraph] => Bottlebrush polymer conjugates for enhanced antisense oligonucleotide therapy in myotonic dystrophy type 1
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Authors
Li, Yao, Oetheimer, Christopher, Wang, Yuyan, Heo, Gyu Seong, Wu, Jiaqi, Chang, Rong, Zhang, Wei, Schneider, Elle, Chen, Junjie, Fang, Yang, Wei, Yun, Nian, Keqing, Zhang, Hengli, Sherman, Lauren, Liu, Yongjian, Zhang, Ke

Lab
pacDNA Inc.; Natick; MA 01760; United States; Department of Bioengineering; Northeastern University; Department of Biology; Northeastern University; College of Professional Studies; Northeastern University; Department of Chemical Engineering; Northeastern University; Copyright © 2026 Oxford University Press; University press partners; Oxford University Press; University of Oxford
Journal
Nucleic Acids Research
Abstract
Abstract. Oligonucleotides are a promising class of genetic medicine for myotonic dystrophy type 1 (DM1), the most common adult-onset muscular dystrophy. H
Keywords/Topics
hindlimb grip strength; bottlebrush polymer conjugates; enhanced antisense oligonucleotide therapy; myotonic dystrophy type; oligonucleotides; genetic medicine; h forelimb; bioseb; baseline
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An easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins, muscular (i.e. myopathy) and neurodegenerative diseases on muscular degeneration. It is widely used in conjunction with the ROTAROD motor coordination test: a normally coordinated rodent will show a decreased latency to fall off the rotating rod if its muscular strength is low. The Grip Strength Test is a must for your research on activity, motor control & coordination, and is particularly well suited for studies on Parkinson's & Huntington's disease.
New features GS4 - 2023: Color display with permanent backlight screen for easier reading, reset by footswitch, Improved battery time, Larger data memory of 500 values, Animal counter, USB port (charging/data transfer)

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