Publications

Latest publication 11/01/2025

Relationship between simvastatin pharmacokinetics and muscle toxicity in male mi

Statins are highly effective in reducing plasma LDL-cholesterol but may be myotoxic. Since the relationship between statin exposure and myotoxicity...

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    [title] => Relationship between simvastatin pharmacokinetics and muscle toxicity in male mi
    [paragraph] => Relationship between simvastatin pharmacokinetics and muscle toxicity in male mice
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Authors
Jamal Bouitbir, Gerda M. Sanvee, Miljenko V. Panajatovic, Natasha Bärenzung Fehrenbach, Théo Fréchard, Madhuri Manivannan, Urs Duthaler, Stephan Krähenbühl



 Lab


Journal
Food and Chemical Toxicology


Abstract
Statins are highly effective in reducing plasma LDL-cholesterol but may be myotoxic. Since the relationship between statin exposure and myotoxicity is…


Keywords/Topics
Simvastatin;Skeletal muscle;Dose-finding study;Pharmacokinetics;Exercise;Atrophy
BIOSEB Instruments Used:
Grip strength test (BIO-GS4)

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An easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins, muscular (i.e. myopathy) and neurodegenerative diseases on muscular degeneration. It is widely used in conjunction with the ROTAROD motor coordination test: a normally coordinated rodent will show a decreased latency to fall off the rotating rod if its muscular strength is low. The Grip Strength Test is a must for your research on activity, motor control & coordination, and is particularly well suited for studies on Parkinson's & Huntington's disease.


New features GS4 - 2023: Color display with permanent backlight screen for easier reading, reset by footswitch, Improved battery time, Larger data memory of 500 values, Animal counter, USB port (charging/data transfer)


forrats.pngformice.png

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