Publications

Latest publication 12/04/2019

Arthritis sensory and motor scale- predicting functional deficits from the clini

In the collagen-induced arthritis (CIA) mouse model, inflammation readouts are usually quantified using operator-dependent clinical scoring...

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    [title] => Arthritis sensory and motor scale- predicting functional deficits from the clini
    [paragraph] => Arthritis sensory and motor scale: predicting functional deficits from the clinical score in collagen-induced arthritis
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Authors
AL Mausset-Bonnefont, M Cren, R Vicente, J Quentin

 Lab
IRMB, University of Montpellier, INSERM, Montpellier, France
Journal
Arthritis Research & Therapy
Abstract
In the collagen-induced arthritis (CIA) mouse model, inflammation readouts are usually quantified using operator-dependent clinical scoring systems, and no systematic relationship with functional deficits has been detected. In this study, we extensively quantified sensory and motor deficits in CIA mice during natural disease progression and therapeutic treatment. Then, we used these data to build a scale to predict functional deficits on the basis of the classical clinical score.
BIOSEB Instruments Used
Static Weight Bearing Touch: Incapacitance Test (BIO-SWB-TOUCH-M),Infrared Actimeter (LE8815)

Keywords/Topics
Arthritis & Osteoarthritis; Joints
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An easy and non pain-inducing solution for assessing the level of discomfort (incapacitance) in the injured paw of a small animal like a rat or a mouse by measuring the Postural Equilibrium “ independently of the operator". The static weight bearing instrument is ideal for your research on analagesia and nociception involving rodents: osteo arthrisis, cartilage degeneration, inflammation models, nerve injury models, and much more... Discover the SWB-Touch: now with a brand new touch-screen console!

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