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Latest publication 04/30/2026

Revisiting MAC as a static measure of anaesthesia: evidence for dynamic response

The presence of a righting reflex is known to vary over time in an individual at the population half-maximal effective anaesthetic concentration (EC50

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    [title] => Revisiting MAC as a static measure of anaesthesia: evidence for dynamic response
    [paragraph] => Revisiting MAC as a static measure of anaesthesia: evidence for dynamic responses under isoflurane in male mice
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Authors
Aden Mandel, Jackson Soohoo, Chloe Deitelzweig, Isha Patkar, Dennis Han, Madona Farag, Andrew McKinstry-Wu

Lab
Laboratory Investigation
Journal
British Journal of Anaesthesia
Abstract
The presence of a righting reflex is known to vary over time in an individual at the population half-maximal effective anaesthetic concentration (EC50
Keywords/Topics
male mice; half-maximal effective anaesthetic concentration; calibrated forceps; anaesthesia; evidence; dynamic responses; isoflurane; time; ec50 paw pinches; bioseb

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A fast and accurate algometer based on an instrumented pincher as an alternative to the Randall-Selitto test: This new analgesia meter developed by Bioseb following Luis-Delgado et al. (2005) allows accurate nociceptive tests to measure mechanical pain threshold on rat or mouse limbs with minimal constraint. Now wireless, to be free from annoying cables!


Instrument for ratsInstrument for mice

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