Publications

Latest publication 09/18/2024

Targeting senescence induced by age or chemotherapy with a polyphenol-rich natur

Accumulating senescent cells within tissues contribute to the progression of aging and age-related diseases. Botanical extracts, rich in...

Array
(
    [id_prestablog_news] => 2333
    [id_shop] => 1
    [date] => 2024-09-18 00:00:00
    [date_modification] => 2024-09-18 00:00:00
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [ishero] => 0
    [prim_key] => 4270
    [id_lang] => 1
    [title] => Targeting senescence induced by age or chemotherapy with a polyphenol-rich natur
    [paragraph] => Targeting senescence induced by age or chemotherapy with a polyphenol-rich natural extract improves longevity and healthspan in mice
    [content] => 
Authors
Zumerle, Sara, Sarill, Miles, Saponaro, Miriam, Colucci, Manuel, Contu, Liliana, Lazzarini, Edoardo, Sartori, Roberta, Pezzini, Camilla, Rinaldi, Anna, Scanu, Anna, Sgrignani, Jacopo, Locatelli, Patrizia, Sabbadin, Marianna, Valdata, Aurora, Brina, Daniela, Giacomini, Isabella, Rizzo, Beatrice, Pierantoni, Alessandra, Sharifi, Saman, Bressan, Silvia, Altomare, Claudia, Goshovska, Yulia, Giraudo, Chiara, Luisetto, Roberto, Iaccarino, Luca, Torcasio, Cristina, Mosole, Simone, Pasquini, Emiliano, Rinaldi, Andrea, Pellegrini, Laura, Peron, Gregorio, Fassan, Matteo, Masiero, Stefano, Giori, Andrea Maria, Dall'Acqua, Stefano, Auwerx, Johan, Cipp , Pietro, Cavalli, Andrea, Bolis, Marco, Sandri, Marco, Barile, Lucio, Montopoli, Monica, Alimonti, Andrea

 Lab

Journal
Nature Aging
Abstract
Accumulating senescent cells within tissues contribute to the progression of aging and age-related diseases. Botanical extracts, rich in phytoconstituents, present a useful resource for discovering therapies that could target senescence and thus improve healthspan. Here, we show that daily oral administration of a standardized extract of Salvia haenkei (Haenkenium (HK)) extended lifespan and healthspan of naturally aged mice. HK treatment inhibited age-induced inflammation, fibrosis and senescence markers across several tissues, as well as increased muscle strength and fur thickness compared with age-matched controls. We also found that HK treatment reduced acutely induced senescence by the chemotherapeutic agent doxorubicin, using p16LUC reporter mice. We profiled the constituent components of HK by mass spectrometry, and identified luteolin-the most concentrated flavonoid in HK-as a senomorphic compound. Mechanistically, by performing surface plasmon resonance and in situ proximity ligation assay, we found that luteolin disrupted the p16-CDK6 interaction. This work demonstrates that administration of HK promotes longevity in mice, possibly by modulating cellular senescence and by disrupting the p16-CDK6 interaction. Botanical extracts offer a valuable resource for identifying therapies. Zumerle, Sarill et al. show that a standardized extract of Salvia haenkei extends lifespan and healthspan in naturally aged mice by modulating inflammation and cellular senescence, and identify the constituent component luteolin as a senomorphic that disrupts the p16-CDK6 interaction.
Keywords/Topics
targeting;senescence;induced;chemotherapy;polyphenol-rich;natural;extract;improves;longevity;healthspan
BIOSEB Instruments Used:
Grip strength test (BIO-GS4)
    [meta_description] => 
    [meta_keywords] => https://www.nature.com/articles/s43587-024-00663-7
    [meta_title] => 
    [link_rewrite] => Targeting-senescence-induced-by-age-or-chemotherapy-with-a-polyphenol-rich-natural-extract-improves-longevity-and-healthspan-in-mice
    [actif_langue] => 1
    [read] => 152
    [count_comments] => 0
    [id] => 2333
    [categories] => Array
        (
            [89] => Array
                (
                    [id_prestablog_categorie] => 89
                    [title] => Aging
                    [link_rewrite] => Aging
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

        )

    [authors] => 
    [paragraph_crop] => Targeting senescence induced by age or chemotherapy with a polyphenol-rich natural extract [...]
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [48] => Array
                (
                    [name] => Grip strength test
                    [description_short] => 
An easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins, muscular (i.e. myopathy) and neurodegenerative diseases on muscular degeneration. It is widely used in conjunction with the ROTAROD motor coordination test: a normally coordinated rodent will show a decreased latency to fall off the rotating rod if its muscular strength is low. The Grip Strength Test is a must for your research on activity, motor control & coordination, and is particularly well suited for studies on Parkinson's & Huntington's disease.
New features GS4 - 2023: Color display with permanent backlight screen for easier reading, reset by footswitch, Improved battery time, Larger data memory of 500 values, Animal counter, USB port (charging/data transfer)

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/en/activity-motor-control-coordination/48-grip-strength-test.html
                )

        )

)
1